Family history and molecular features of children, adolescents, and young adults with colorectal carcinoma.
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ABSTRACT:
SUBMITTER: Durno C
PROVIDER: S-EPMC1774876 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Publications
Family history and molecular features of children, adolescents, and young adults with colorectal carcinoma.
Durno C C Aronson M M Bapat B B Cohen Z Z Gallinger S S
Gut 20050421 8
<h4>Background</h4>Colorectal cancer is extremely rare in childhood. Published case series reporting children and adolescents with colorectal cancer have not focused on the underlying genetic aspects of the tumour or genetic susceptibility of the families.<h4>Aims</h4>We examined a cohort of patients with early onset colorectal cancer to determine whether a specific genetic predisposition could be elucidated. In particular, we focused on whether DNA mismatch repair gene deficiency which causes h ...[more]
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