Ontology highlight
ABSTRACT:
SUBMITTER: Law RH
PROVIDER: S-EPMC1779521 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Law Ruby H P RH Zhang Qingwei Q McGowan Sheena S Buckle Ashley M AM Silverman Gary A GA Wong Wilson W Rosado Carlos J CJ Langendorf Chris G CG Pike Rob N RN Bird Philip I PI Whisstock James C JC
Genome biology 20060530 5
Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in pathogenic, inactive polymers. ...[more]