Ontology highlight
ABSTRACT:
SUBMITTER: Wang QF
PROVIDER: S-EPMC1779597 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Wang Qian-fei QF Prabhakar Shyam S Wang Qianben Q Moses Alan M AM Chanan Sumita S Brown Myles M Eisen Michael B MB Cheng Jan-Fang JF Rubin Edward M EM Boffelli Dario D
Genome biology 20060802 8
<h4>Background</h4>Sequence changes in regulatory regions have often been invoked to explain phenotypic divergence among species, but molecular examples of this have been difficult to obtain.<h4>Results</h4>In this study we identified an anthropoid primate-specific sequence element that contributed to the regulatory evolution of the low-density lipoprotein receptor. Using a combination of close and distant species genomic sequence comparisons coupled with in vivo and in vitro studies, we found t ...[more]