Ontology highlight
ABSTRACT:
SUBMITTER: Nolz JC
PROVIDER: S-EPMC1779663 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Nolz Jeffrey C JC Gomez Timothy S TS Zhu Peimin P Li Shuixing S Medeiros Ricardo B RB Shimizu Yoji Y Burkhardt Janis K JK Freedman Bruce D BD Billadeau Daniel D DD
Current biology : CB 20060101 1
<h4>Background</h4>The engagement of the T cell receptor results in actin cytoskeletal reorganization at the immune synapse (IS) and the triggering of biochemical signaling cascades leading to gene regulation and, ultimately, cellular activation. Recent studies have identified the WAVE family of proteins as critical mediators of Rac1-induced actin reorganization in other cell types. However, whether these proteins participate in actin reorganization at the IS or signaling pathways in T cells has ...[more]