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Evolutionarily new sequences expressed in tumors.


ABSTRACT: BACKGROUND:Earlier we suggested the concept of the positive evolutionary role of tumors. According to this concept, tumors provide conditions for the expression of evolutionarily new and/or sleeping genes in their cells. Thus, tumors are considered as evolutionary proving ground or reservoir of expression. To support this concept we have previously characterized in silico and experimentally a new class of human tumor-related transcribed sequences. RESULTS:In this article we describe results of further studies of previously described tumor-related sequences. The results of molecular phylogeny studies, Southern hybridization experiments and computational comparison with genomes of other species are presented. CONCLUSION:These results suggest that these previously described tumor-related human transcripts are also relatively evolutionarily new.

SUBMITTER: Kozlov AP 

PROVIDER: S-EPMC1779766 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature

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<h4>Background</h4>Earlier we suggested the concept of the positive evolutionary role of tumors. According to this concept, tumors provide conditions for the expression of evolutionarily new and/or sleeping genes in their cells. Thus, tumors are considered as evolutionary proving ground or reservoir of expression. To support this concept we have previously characterized in silico and experimentally a new class of human tumor-related transcribed sequences.<h4>Results</h4>In this article we descri  ...[more]

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