Ontology highlight
ABSTRACT:
SUBMITTER: Bock O
PROVIDER: S-EPMC1780160 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Bock Oliver O Neuse Johanne J Hussein Kais K Brakensiek Kai K Buesche Guntram G Buhr Thomas T Wiese Birgitt B Kreipe Hans H
The American journal of pathology 20060801 2
Bone marrow fibrosis in chronic idiopathic myelofibrosis (cIMF) most likely represents an imbalance between synthesis and turnover of collagen fibers. Because the JAK-STAT signaling pathway is involved in the regulation of genes encoding matrix metalloproteinases (MMPs), we examined the expression of MMPs, their tissue inhibitors (TIMPs), and collagen types in relation to the JAK2 status (V617F mutation versus wild-type) in cIMF (n = 64). Whereas no correlation was found between the JAK2 status ...[more]