Yeast cells provide insight into alpha-synuclein biology and pathobiology.
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ABSTRACT:
SUBMITTER: Outeiro TF
PROVIDER: S-EPMC1780172 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Publications
Yeast cells provide insight into alpha-synuclein biology and pathobiology.
Outeiro Tiago Fleming TF Lindquist Susan S
Science (New York, N.Y.) 20031201 5651
Alpha-synuclein is implicated in several neurodegenerative disorders, such as Parkinson's disease and multiple system atrophy, yet its functions remain obscure. When expressed in yeast, alpha-synuclein associated with the plasma membrane in a highly selective manner, before forming cytoplasmic inclusions through a concentration-dependent, nucleated process. Alpha-synuclein inhibited phospholipase D, induced lipid droplet accumulation, and affected vesicle trafficking. This readily manipulable sy ...[more]
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