Ontology highlight
ABSTRACT:
SUBMITTER: Petrache I
PROVIDER: S-EPMC1780181 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Petrache Irina I Fijalkowska Iwona I Medler Terry R TR Skirball Jarrett J Cruz Pedro P Zhen Lijie L Petrache Horia I HI Flotte Terence R TR Tuder Rubin M RM
The American journal of pathology 20061001 4
alpha-1 Antitrypsin (A1AT) is an abundant circulating serpin with a postulated function in the lung of potently inhibiting neutrophil-derived proteases. Emphysema attributable to A1AT deficiency led to the concept that a protease/anti-protease imbalance mediates cigarette smoke-induced emphysema. We hypothesized that A1AT has other pathobiological relevant functions in addition to elastase inhibition. We demonstrate a direct prosurvival effect of A1AT through inhibition of lung alveolar endothel ...[more]