Ontology highlight
ABSTRACT:
SUBMITTER: Takeuchi J
PROVIDER: S-EPMC1782366 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
The EMBO journal 20061207 1
To determine the minimum requirements for substrate recognition and processing by proteasomes, the functional elements of a ubiquitin-independent degradation tag were dissected. The 37-residue C-terminus of ornithine decarboxylase (cODC) is a native degron, which also functions when appended to diverse proteins. Mutating the cysteine 441 residue within cODC impaired its proteasome association in the context of ornithine decarboxylase and prevented the turnover of GFP-cODC in yeast cells. Degrada ...[more]