Knockdown of Nurr1 in the rat hippocampus: implications to spatial discrimination learning and memory.

ABSTRACT: Nurr1 expression is up-regulated in the brain following associative learning experiences, but its relevance to cognitive processes remains unclear. In these studies, rats initially received bilateral hippocampal infusions of control or antisense oligodeoxynucleotides (ODNs) 1 h prior to training in a holeboard spatial discrimination task. Such pre-training infusions of nurr1 antisense ODNs caused a moderate effect in learning the task and also impaired LTM tested 7 d later. In a second experiment, ODN infusions were given immediately after the animals had received two sessions of training, during which all animals showed normal learning. Although antisense treated rats were significantly impaired during the post-infusion stages of acquisition of the task, no group differences were observed

SUBMITTER: Colon-Cesario WI 

PROVIDER: S-EPMC1783627 | biostudies-literature | 2006 Nov-Dec

REPOSITORIES: biostudies-literature