Ontology highlight
ABSTRACT:
SUBMITTER: Gao XG
PROVIDER: S-EPMC17842 | biostudies-literature | 1999 Aug
REPOSITORIES: biostudies-literature
Gao X G XG Maldonado E E Pérez-Montfort R R Garza-Ramos G G de Gómez-Puyou M T MT Gómez-Puyou A A Rodríguez-Romero A A
Proceedings of the National Academy of Sciences of the United States of America 19990801 18
To gain insight into the mechanisms of enzyme catalysis in organic solvents, the x-ray structure of some monomeric enzymes in organic solvents was determined. However, it remained to be explored whether the structure of oligomeric proteins is also amenable to such analysis. The field acquired new perspectives when it was proposed that the x-ray structure of enzymes in nonaqueous media could reveal binding sites for organic solvents that in principle could represent the starting point for drug de ...[more]