Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish.
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ABSTRACT:
SUBMITTER: Rai K
PROVIDER: S-EPMC1785123 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Publications
Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish.
Rai Kunal K Chidester Stephanie S Zavala Chad V CV Manos Elizabeth J EJ James Smitha R SR Karpf Adam R AR Jones David A DA Cairns Bradley R BR
Genes & development 20070201 3
The roles of DNA methyltransferase-2 (DNMT2) enzymes are controversial; whether DNMT2 functions primarily as a nuclear DNA methyltransferase or as a cytoplasmic tRNA methyltransferase, and whether DNMT2 activity impacts development, as dnmt2 mutant mice or Drosophila lack phenotypes. Here we show that morpholino knockdown of Dnmt2 protein in zebrafish embryos confers differentiation defects in particular organs, including the retina, liver, and brain. Importantly, proper organ differentiation re ...[more]
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