Unknown

Dataset Information

0

Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling.

ABSTRACT: Human T-cell leukemia virus type-1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and neurological syndromes. HTLV-1 encodes the oncoprotein Tax-1, which modulates viral and cellular gene expression leading to T-cell transformation. Guanine nucleotide-binding proteins (G proteins) and G protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins known and are involved in the regulation of most biological functions. Here, we report an interaction between HTLV-1 Tax oncoprotein and the G-protein beta subunit. Interestingly, though the G-protein beta subunit inhibits Tax-mediated viral transcription, Tax-1 perturbs G-protein beta subcellular localization. Functional evidence for these observations was obtained using conditional Tax-1-expressing transformed T-lymphocytes, where Tax expression correlated with activation of the SDF-1/CXCR4 axis. Our data indicated that HTLV-1 developed a strategy based on the activation of the SDF-1/CXCR4 axis in the infected cell; this could have tremendous implications for new therapeutic strategies.

SUBMITTER: Twizere JC 

PROVIDER: S-EPMC1785145 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Human T-cell leukemia virus type-1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and neurological syndromes. HTLV-1 encodes the oncoprotein Tax-1, which modulates viral and cellular gene expression leading to T-cell transformation. Guanine nucleotide-binding proteins (G proteins) and G protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins known and are involved in the regulation of most biological functions. Here, we report an interaction between HTLV-1 T  ...[more]

Similar Datasets

Unknown The four and a half LIM family members are novel interactants of the human T-cell leukemia virus type 1 Tax oncoprotein.
| S-EPMC3700305 | biostudies-literature
Unknown Human T cell leukemia virus type I tax-induced IκB-ζ modulates tax-dependent and tax-independent gene expression in T cells.
| S-EPMC3769889 | biostudies-literature
Unknown Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein.
| S-EPMC1291224 | biostudies-literature
Unknown Phosphorylation of the human T-cell leukemia virus type 1 transactivator tax on adjacent serine residues is critical for tax activation.
| S-EPMC103881 | biostudies-literature
Unknown Stable ubiquitination of human T-cell leukemia virus type 1 tax is required for proteasome binding.
| S-EPMC523289 | biostudies-other
Unknown The human T-cell leukemia virus type-1 tax oncoprotein dissociates NF-κB p65<sup>RelA</sup>-Stathmin complexes and causes catastrophic mitotic spindle damage and genomic instability.
| S-EPMC6940561 | biostudies-literature
Unknown Human T-cell leukemia virus I tax protein sensitizes p53-mutant cells to DNA damage.
| S-EPMC5939382 | biostudies-other
Unknown Identification of poly(ADP-ribose) polymerase as a transcriptional coactivator of the human T-cell leukemia virus type 1 Tax protein.
| S-EPMC111697 | biostudies-literature
Unknown PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation.
| S-EPMC2676091 | biostudies-literature
Unknown In vivo antagonistic role of the Human T-Cell Leukemia Virus Type 1 regulatory proteins Tax and HBZ.
| S-EPMC7817025 | biostudies-literature