Ontology highlight
ABSTRACT:
SUBMITTER: Arai S
PROVIDER: S-EPMC1793902 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Arai Satoko S Miyake Katsuhisa K Voit Renate R Nemoto Shino S Wakeland Edward K EK Grummt Ingrid I Miyazaki Toru T
Proceedings of the National Academy of Sciences of the United States of America 20070205 7
Accumulating evidence has shown that many molecules, including some cyclin-dependent kinases (Cdks) and cyclins, as well as the death-effector domain (DED)-containing FADD, function for both apoptosis and cell cycle. Here we identified that DEDD, which also possesses the DED domain, acts as a novel inhibitor of the mitotic Cdk1/cyclin B1 complex. DEDD associates with mitotic Cdk1/cyclin B1 complexes via direct binding to cyclin B1 and reduces their function. In agreement, kinase activity of nucl ...[more]