Ontology highlight
ABSTRACT:
SUBMITTER: Duarte NC
PROVIDER: S-EPMC1794290 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Duarte Natalie C NC Becker Scott A SA Jamshidi Neema N Thiele Ines I Mo Monica L ML Vo Thuy D TD Srivas Rohith R Palsson Bernhard Ø BØ
Proceedings of the National Academy of Sciences of the United States of America 20070131 6
Metabolism is a vital cellular process, and its malfunction is a major contributor to human disease. Metabolic networks are complex and highly interconnected, and thus systems-level computational approaches are required to elucidate and understand metabolic genotype-phenotype relationships. We have manually reconstructed the global human metabolic network based on Build 35 of the genome annotation and a comprehensive evaluation of >50 years of legacy data (i.e., bibliomic data). Herein we descri ...[more]