How complete are current yeast and human protein-interaction networks?
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ABSTRACT:
SUBMITTER: Hart GT
PROVIDER: S-EPMC1794583 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Publications
How complete are current yeast and human protein-interaction networks?
Hart G Traver GT Ramani Arun K AK Marcotte Edward M EM
Genome biology 20060101 11
We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data might help separate true from false interactions. ...[more]
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