Ontology highlight
ABSTRACT:
SUBMITTER: Kim JO
PROVIDER: S-EPMC1797512 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Journal of virology 20061108 3
Phospholipase A2 (PLA2) proteins affect cellular activation, signal transduction, and possibly innate immunity. A specific secretory PLA2, sPLA2-X, is shown here to neutralize human immunodeficiency virus type 1 (HIV-1) through degradation of the viral membrane. Catalytic function was required for antiviral activity, and the target cells of infection were unaffected. sPLA2-X potently reduced gene transfer of HIV-1 Env-pseudotyped lentivirus vectors and inhibited the replication of both CCR5- and ...[more]