Ontology highlight
ABSTRACT:
SUBMITTER: Trajkovic M
PROVIDER: S-EPMC1797602 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Trajkovic Marija M Visser Theo J TJ Mittag Jens J Horn Sigrun S Lukas Jan J Darras Veerle M VM Raivich Genadij G Bauer Karl K Heuer Heike H
The Journal of clinical investigation 20070222 3
In humans, inactivating mutations in the gene of the thyroid hormone transporter monocarboxylate transporter 8 (MCT8; SLC16A2) lead to severe forms of psychomotor retardation combined with imbalanced thyroid hormone serum levels. The MCT8-null mice described here, however, developed without overt deficits but also exhibited distorted 3,5,3'-triiodothyronine (T3) and thyroxine (T4) serum levels, resulting in increased hepatic activity of type 1 deiodinase (D1). In the mutants' brains, entry of T4 ...[more]