Ontology highlight
ABSTRACT:
SUBMITTER: Nickels BE
PROVIDER: S-EPMC1797609 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Nickels Bryce E BE Roberts Christine W CW Roberts Jeffrey W JW Hochschild Ann A
Molecular cell 20061101 3
The bacterial RNA polymerase (RNAP) holoenzyme consists of a catalytic core enzyme (alpha(2)betabeta'omega) complexed with a sigma factor that is required for promoter-specific transcription initiation. During early elongation, the stability of interactions between sigma(70) (the primary sigma factor in Escherichia coli) and core decreases due to an ordered displacement of segments of sigma(70) from core triggered by growth of the nascent RNA. Here we demonstrate that the nascent RNA-mediated de ...[more]