Ontology highlight
ABSTRACT:
SUBMITTER: Kaipainen A
PROVIDER: S-EPMC1800345 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Kaipainen Arja A Kieran Mark W MW Huang Sui S Butterfield Catherine C Bielenberg Diane D Mostoslavsky Gustavo G Mulligan Richard R Folkman Judah J Panigrahy Dipak D
PloS one 20070228 2
Inflammation in the tumor bed can either promote or inhibit tumor growth. Peroxisome proliferator-activated receptor (PPAR)alpha is a central transcriptional suppressor of inflammation, and may therefore modulate tumor growth. Here we show that PPARalpha deficiency in the host leads to overt inflammation that suppresses angiogenesis via excess production of the endogenous angiogenesis inhibitor thrombospondin-1 and prevents tumor growth. Bone marrow transplantation and granulocyte depletion show ...[more]