Ontology highlight
ABSTRACT:
SUBMITTER: Song H
PROVIDER: S-EPMC1800910 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Song Honglin H Ramus Susan J SJ Kjaer Susanne Krüger SK Hogdall Estrid E Dicioccio Richard A RA Whittemore Alice S AS McGuire Valerie V Hogdall Claus C Jacobs Ian J IJ Easton Douglas F DF Ponder Bruce A J BA Dunning Alison M AM Gayther Simon A SA Pharoah Paul D P PD
PloS one 20070307 3
<h4>Background</h4>BRIP1 interacts with BRCA1 and functions in regulating DNA double strand break repair pathways. Germline BRIP1 mutations are associated with breast cancer and Fanconi anemia. Thus, common variants in the BRIP1 are candidates for breast and ovarian cancer susceptibility.<h4>Methods</h4>We used a SNP tagging approach to evaluate the association between common variants (minor allele frequency>or=0.05) in BRIP1 and the risks of breast cancer and invasive ovarian cancer. 12 tagging ...[more]