Ontology highlight
ABSTRACT:
SUBMITTER: Mitchell LE
PROVIDER: S-EPMC1801363 | biostudies-literature | 1995 Nov
REPOSITORIES: biostudies-literature
Mitchell L E LE Healey S C SC Chenevix-Trench G G
American journal of human genetics 19951101 5
Recent studies suggest that the familial aggregation of nonsyndromic cleft lip with or without cleft palate (CL +/- P) is likely to be attributable to the effects of several susceptibility loci, acting in a multiplicative fashion. Two potential CL +/- P susceptibility loci (CSL), transforming growth factor alpha (TGFA) and retinoic acid receptor (RARA), have been identified through association studies. In addition, recent evidence of linkage between CL +/- P and two markers (D4S175 and D4S192) i ...[more]