Ontology highlight
ABSTRACT:
SUBMITTER: Alam MT
PROVIDER: S-EPMC1803105 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Alam Mohammad Tauqeer MT Bora Hema H Bharti Praveen K PK Saifi Muheet A MA Das Manoj K MK Dev Vas V Kumar Ashwani A Singh Neeru N Dash Aditya P AP Das Brahmananda B Wajihullah Sharma Yagya D YD
Antimicrobial agents and chemotherapy 20061228 3
The antifolate drugs sulfadoxine and pyrimethamine are commonly used to treat Plasmodium falciparum malaria. However, they can also affect the Plasmodium vivax parasite if it coexists with P. falciparum, as both species have common drug targets. Resistance to the antifolate drugs arises due to point mutations in the target enzymes of the respective parasite. To assess the cross-species impact of antifolate drug treatment, we describe here the dihydrofolate reductase (DHFR) mutations among field ...[more]