Ontology highlight
ABSTRACT:
SUBMITTER: Hanson SM
PROVIDER: S-EPMC1805568 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Hanson Susan M SM Gurevich Eugenia V EV Vishnivetskiy Sergey A SA Ahmed Mohamed R MR Song Xiufeng X Gurevich Vsevolod V VV
Proceedings of the National Academy of Sciences of the United States of America 20070220 9
Arrestins (Arrs) are ubiquitous regulators of the most numerous family of signaling proteins, G protein-coupled receptors. Two models of the Arr-receptor interaction have been proposed: the binding of one Arr to an individual receptor or to two receptors in a dimer. To determine the binding stoichiometry in vivo, we used rod photoreceptors where rhodopsin (Rh) and Arr are expressed at comparably high levels and where Arr localization in the light is determined by its binding to activated Rh. Gen ...[more]