Ontology highlight
ABSTRACT:
SUBMITTER: Schmid D
PROVIDER: S-EPMC1805710 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Schmid Dorothee D Pypaert Marc M Münz Christian C
Immunity 20061221 1
Major histocompatibility complex (MHC) class II molecules present products of lysosomal proteolysis to CD4(+) T cells. Although extracellular antigen uptake is considered to be the main source of MHC class II ligands, a few intracellular antigens have been described to gain access to MHC class II loading after macroautophagy. However, the general relevance and efficacy of this pathway is unknown. Here we demonstrated constitutive autophagosome formation in MHC class II-positive cells, including ...[more]