Ontology highlight
ABSTRACT:
SUBMITTER: Kaushik R
PROVIDER: S-EPMC181556 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
Kaushik Rachna R Yu Fengwei F Chia William W Yang Xiaohang X Bahri Sami S
Molecular biology of the cell 20030503 8
Mammalian LGN/AGS3 proteins and their Drosophila Pins orthologue are cytoplasmic regulators of G-protein signaling. In Drosophila, Pins localizes to the lateral cortex of polarized epithelial cells and to the apical cortex of neuroblasts where it plays important roles in their asymmetric division. Using overexpression studies in different cell line systems, we demonstrate here that, like Drosophila Pins, LGN can exhibit enriched localization at the cell cortex, depending on the cell cycle and th ...[more]