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Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs.

ABSTRACT: Canine hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is a rare, naturally occurring inherited cancer syndrome observed in dogs. Genetic linkage analysis of an RCND-informative pedigree has identified a linkage group flanking RCND (CHP14-C05.377-C05.414-FH2383-C05. 771-[RCND-CPH18]-C02608-GLUT4-TP53-ZuBe Ca6-AHT141-FH2140-FH2594) thus localizing the disease to a small region of canine chromosome 5. The closest marker, C02608, is linked to RCND with a recombination fraction (theta) of 0.016, supported by a logarithm of odds score of 16.7. C02608 and the adjacent linked markers map to a region of the canine genome corresponding to portions of human chromosomes 1p and 17p. A combination of linkage analysis and direct sequencing eliminate several likely candidate genes, including tuberous sclerosis 1 and 2 genes (TSC1 and TSC2) and the tumor suppressor gene TP53. These data suggest that RCND may be caused by a previously unidentified tumor suppressor gene and highlight the potential for canine genetics in the study of human disease predisposition.

SUBMITTER: Jonasdottir TJ

PROVIDER: S-EPMC18172 | biostudies-literature | 2000 Apr

REPOSITORIES: biostudies-literature

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Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs.

Jónasdóttir T J TJ Mellersh C S CS Moe L L Heggebø R R Gamlem H H Ostrander E A EA Lingaas F F

Proceedings of the National Academy of Sciences of the United States of America 20000401 8

Canine hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is a rare, naturally occurring inherited cancer syndrome observed in dogs. Genetic linkage analysis of an RCND-informative pedigree has identified a linkage group flanking RCND (CHP14-C05.377-C05.414-FH2383-C05. 771-[RCND-CPH18]-C02608-GLUT4-TP53-ZuBe Ca6-AHT141-FH2140-FH2594) thus localizing the disease to a small region of canine chromosome 5. The closest marker, C02608, is linked to RCND with a recombinat ...[more]

PMID: 10759551

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Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs.

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Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs.

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