Ontology highlight
ABSTRACT:
SUBMITTER: Carpenter EP
PROVIDER: S-EPMC1817638 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Carpenter Elisabeth P EP Corbett Anne A Thomson Hellen H Adacha Jolanta J Jensen Kirsten K Bergeron Julien J Kasampalidis Ioannis I Exley Rachel R Winterbotham Megan M Tang Christoph C Baldwin Geoff S GS Freemont Paul P
The EMBO journal 20070222 5
Oxidative stress is a principal cause of DNA damage, and mechanisms to repair this damage are among the most highly conserved of biological processes. Oxidative stress is also used by phagocytes to attack bacterial pathogens in defence of the host. We have identified and characterised two apurinic/apyrimidinic (AP) endonuclease paralogues in the human pathogen Neisseria meningitidis. The presence of multiple versions of DNA repair enzymes in a single organism is usually thought to reflect redund ...[more]