Ontology highlight
ABSTRACT:
SUBMITTER: Trifilo MJ
PROVIDER: S-EPMC1820586 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20060701 5783
We investigated extraneural manifestations in scrapie-infected transgenic mice expressing prion protein lacking the glycophosphatydylinositol membrane anchor. In the brain, blood, and heart, both abnormal protease-resistant prion protein (PrPres) and prion infectivity were readily detected by immunoblot and by inoculation into nontransgenic recipients. The titer of infectious scrapie in blood plasma exceeded 10(7) 50% infectious doses per milliliter. The hearts of these transgenic mice contained ...[more]