Unknown

Dataset Information

0

Prion-induced amyloid heart disease with high blood infectivity in transgenic mice.

ABSTRACT: We investigated extraneural manifestations in scrapie-infected transgenic mice expressing prion protein lacking the glycophosphatydylinositol membrane anchor. In the brain, blood, and heart, both abnormal protease-resistant prion protein (PrPres) and prion infectivity were readily detected by immunoblot and by inoculation into nontransgenic recipients. The titer of infectious scrapie in blood plasma exceeded 10(7) 50% infectious doses per milliliter. The hearts of these transgenic mice contained PrPres-positive amyloid deposits that led to myocardial stiffness and cardiac disease.

SUBMITTER: Trifilo MJ 

PROVIDER: S-EPMC1820586 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

We investigated extraneural manifestations in scrapie-infected transgenic mice expressing prion protein lacking the glycophosphatydylinositol membrane anchor. In the brain, blood, and heart, both abnormal protease-resistant prion protein (PrPres) and prion infectivity were readily detected by immunoblot and by inoculation into nontransgenic recipients. The titer of infectious scrapie in blood plasma exceeded 10(7) 50% infectious doses per milliliter. The hearts of these transgenic mice contained  ...[more]

Similar Datasets

Unknown Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease.
| S-EPMC4400166 | biostudies-literature
Unknown Correction: Transgenic Fatal Familial Insomnia Mice Indicate Prion Infectivity-Independent Mechanisms of Pathogenesis and Phenotypic Expression of Disease.
| S-EPMC4492966 | biostudies-literature
Unknown Immunization of cervidized transgenic mice with multimeric deer prion protein induces self-antibodies that antagonize chronic wasting disease infectivity in vitro.
| S-EPMC5585258 | biostudies-literature
Unknown Preclinical detection of infectivity and disease-specific PrP in blood throughout the incubation period of prion disease.
| S-EPMC4668555 | biostudies-other
Unknown Reduction of prion infectivity in packed red blood cells.
| S-EPMC2606671 | biostudies-literature
Unknown Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice.
| S-EPMC3807058 | biostudies-literature
Unknown Prion infectivity in variant Creutzfeldt-Jakob disease rectum.
| S-EPMC1856674 | biostudies-literature
Unknown Human prion strain selection in transgenic mice.
| S-EPMC2935907 | biostudies-literature
Unknown B cells and platelets harbor prion infectivity in the blood of deer infected with chronic wasting disease.
| S-EPMC2863796 | biostudies-other
Unknown Continuation of exercise is necessary to inhibit high fat diet-induced ?-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice.
| S-EPMC3762856 | biostudies-other