Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC1820674 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Liu Yu Y Asakura Masanori M Inoue Hironori H Nakamura Teruya T Sano Motoaki M Niu Zhiyv Z Chen Michelle M Schwartz Robert J RJ Schneider Michael D MD
Proceedings of the National Academy of Sciences of the United States of America 20070228 10
Early steps for cardiac specification are problematic for the study of mammalian embryos, which has favored using pluripotent cells that recapitulate cardiac myogenesis. Furthermore, circuits governing cardiac specification have relevance to the application of ES cells and other cells for heart repair. In mouse teratocarcinoma cells, canonical Wnts that inhibit heart formation in avian or amphibian embryos and explants activate cardiogenesis, paradoxically. Here, we show that the Wnt/beta-cateni ...[more]