Ontology highlight
ABSTRACT:
SUBMITTER: Wu H
PROVIDER: S-EPMC1820691 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Wu Hui H Boackle Susan A SA Hanvivadhanakul Punchong P Ulgiati Daniela D Grossman Jennifer M JM Lee Youngho Y Shen Nan N Abraham Lawrence J LJ Mercer Timothy R TR Park Elly E Hebert Lee A LA Rovin Brad H BH Birmingham Dan J DJ Chang Deh-Ming DM Chen Chung Jen CJ McCurdy Deborah D Badsha Humeira M HM Thong Bernard Y H BY Chng Hiok H HH Arnett Frank C FC Wallace Daniel J DJ Yu C Yung CY Hahn Bevra H BH Cantor Rita M RM Tsao Betty P BP
Proceedings of the National Academy of Sciences of the United States of America 20070222 10
A genomic region on distal mouse chromosome 1 and its syntenic human counterpart 1q23-42 show strong evidence of harboring lupus susceptibility genes. We found evidence of linkage at 1q32.2 in a targeted genome scan of 1q21-43 in 126 lupus multiplex families containing 151 affected sibpairs (nonparametric linkage score 2.52, P = 0.006). A positional candidate gene at 1q32.2, complement receptor 2 (CR2), is also a candidate in the murine Sle1c lupus susceptibility locus. To explore its role in hu ...[more]