Ontology highlight
ABSTRACT:
SUBMITTER: Amberg GC
PROVIDER: S-EPMC182211 | biostudies-literature | 2003 Sep
REPOSITORIES: biostudies-literature
Amberg Gregory C GC Bonev Adrian D AD Rossow Charles F CF Nelson Mark T MT Santana Luis F LF
The Journal of clinical investigation 20030901 5
Hypertension is a clinical syndrome characterized by increased vascular tone. However, the molecular mechanisms underlying vascular dysfunction during acquired hypertension remain unresolved. Localized intracellular Ca2+ release events through ryanodine receptors (Ca2+ sparks) in the sarcoplasmic reticulum are tightly coupled to the activation of large-conductance, Ca2+-activated K+ (BK) channels to provide a hyperpolarizing influence that opposes vasoconstriction. In this study we tested the hy ...[more]