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Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16.


ABSTRACT: Hookworm infection is one of most important parasitic infection of humans, occurring in 740 million people. Here we report the protective vaccination of dogs with Ac-16, an immunodominant surface antigen from the hookworm Ancylostoma caninum. We show that immunization with Ac-16 formulated with AS03 elicited specific humoral and cellular immune responses and provided partial protection against hookworm infection and morbidity as evidenced by a significant reduction of hookworm egg counts (64% reduction; P = 0.0078) and worm-induced blood loss (P < 0.05). Moreover, specific anti-Ac-16 antibodies recognized the native protein on the surface of third-stage larvae and blocked their migration through tissue in vitro. Our data support the use of Ac-16 as a potential candidate for vaccination against hookworm infection.

SUBMITTER: Fujiwara RT 

PROVIDER: S-EPMC1828853 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature

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Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16.

Fujiwara Ricardo T RT   Zhan Bin B   Mendez Susana S   Loukas Alex A   Bueno Lilian L LL   Wang Yan Y   Plieskatt Jordan J   Oksov Yelena Y   Lustigman Sara S   Bottazzi Maria Elena ME   Hotez Peter P   Bethony Jeffrey M JM  

Clinical and vaccine immunology : CVI 20070131 3


Hookworm infection is one of most important parasitic infection of humans, occurring in 740 million people. Here we report the protective vaccination of dogs with Ac-16, an immunodominant surface antigen from the hookworm Ancylostoma caninum. We show that immunization with Ac-16 formulated with AS03 elicited specific humoral and cellular immune responses and provided partial protection against hookworm infection and morbidity as evidenced by a significant reduction of hookworm egg counts (64% re  ...[more]

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