Ontology highlight
ABSTRACT:
SUBMITTER: Fujiwara RT
PROVIDER: S-EPMC1828853 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Fujiwara Ricardo T RT Zhan Bin B Mendez Susana S Loukas Alex A Bueno Lilian L LL Wang Yan Y Plieskatt Jordan J Oksov Yelena Y Lustigman Sara S Bottazzi Maria Elena ME Hotez Peter P Bethony Jeffrey M JM
Clinical and vaccine immunology : CVI 20070131 3
Hookworm infection is one of most important parasitic infection of humans, occurring in 740 million people. Here we report the protective vaccination of dogs with Ac-16, an immunodominant surface antigen from the hookworm Ancylostoma caninum. We show that immunization with Ac-16 formulated with AS03 elicited specific humoral and cellular immune responses and provided partial protection against hookworm infection and morbidity as evidenced by a significant reduction of hookworm egg counts (64% re ...[more]