Efficient route to C2 symmetric heterocyclic backbone modified cyclic peptides.
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ABSTRACT:
SUBMITTER: van Maarseveen JH
PROVIDER: S-EPMC1829324 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Publications
Efficient route to C2 symmetric heterocyclic backbone modified cyclic peptides.
van Maarseveen Jan H JH Horne W Seth WS Ghadiri M Reza MR
Organic letters 20050901 20
[reaction: see text] A tandem dimerization-macrocyclization approach using 1,3-dipolar azide-alkyne cycloaddition reactions has been employed in the facile and convergent solution phase syntheses of C2 symmetric cyclic peptide scaffolds bearing triazole epsilon2-amino acids as dipeptide surrogates. ...[more]
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