Ontology highlight
ABSTRACT:
SUBMITTER: Xia Y
PROVIDER: S-EPMC1829326 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Xia Yan Y Wang Ji J Liu Ta-Jen TJ Yung W K Alfred WK Hunter Tony T Lu Zhimin Z
Molecular cell 20070101 2
c-Jun, a major transcription factor in the activating protein 1 (AP-1) family of regulatory proteins, is activated by many physiologic and pathologic stimuli. However, whether c-jun is regulated by epigenetic modification of chromatin structure is not clear. We showed here that c-jun was transcriptionally repressed in response to osmotic stress via a truncated HDAC3 generated by caspase-7-dependent cleavage at aspartic acid 391. The activation of caspase-7, which is independent of cytochrome c r ...[more]