Ontology highlight
ABSTRACT:
SUBMITTER: Behm-Ansmant I
PROVIDER: S-EPMC1829367 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Behm-Ansmant Isabelle I Gatfield David D Rehwinkel Jan J Hilgers Valérie V Izaurralde Elisa E
The EMBO journal 20070222 6
The nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs with premature translation termination codons (PTCs). The mechanisms by which PTCs and natural stop codons are discriminated remain unclear. We show that the position of stops relative to the poly(A) tail (and thus of PABPC1) is a critical determinant for PTC definition in Drosophila melanogaster. Indeed, tethering of PABPC1 downstream of a PTC abolishes NMD. Conversely, natural stops trigger NMD when the length of the 3' UTR is incre ...[more]