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Positioning of chemosensory clusters in E. coli and its relation to cell division.

ABSTRACT: Chemotaxis receptors and associated signalling proteins in Escherichia coli form clusters that consist of thousands of molecules and are the largest native protein complexes described to date in bacteria. Clusters are located at the cell poles and laterally along the cell body, and play an important role in signal transduction. Much work has been done to study the structure and function of receptor clusters, but the significance of their positioning and the underlying mechanisms are not understood. Here, we used fluorescence imaging to study cluster distribution and follow cluster dynamics during cell growth. Our data show that lateral clusters localise to specific periodic positions along the cell body, which mark future division sites and are involved in the localisation of the replication machinery. The chemoreceptor cluster positioning is thus intricately related to the overall structure and division of an E. coli cell.

SUBMITTER: Thiem S

PROVIDER: S-EPMC1829377 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature

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Positioning of chemosensory clusters in E. coli and its relation to cell division.

Thiem Sebastian S Kentner David D Sourjik Victor V

The EMBO journal 20070301 6

Chemotaxis receptors and associated signalling proteins in Escherichia coli form clusters that consist of thousands of molecules and are the largest native protein complexes described to date in bacteria. Clusters are located at the cell poles and laterally along the cell body, and play an important role in signal transduction. Much work has been done to study the structure and function of receptor clusters, but the significance of their positioning and the underlying mechanisms are not understo ...[more]

PMID: 17332753

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