Ontology highlight
ABSTRACT:
SUBMITTER: Takasaki N
PROVIDER: S-EPMC1829384 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Takasaki Nobuyoshi N Kurokawa Daisuke D Nakayama Rika R Nakayama Jun-Ichi J Aizawa Shinichi S
The EMBO journal 20070301 6
The mouse homeobox gene Otx2 plays essential roles at each step and in every tissue during head development. We have previously identified a series of enhancers that are responsible for driving the Otx2 expression in these contexts. Among them the AN enhancer, existing 92 kb 5' upstream, directs Otx2 expression in anterior neuroectoderm (AN) at the headfold stage. Analysis of the enhancer mutant Otx2(DeltaAN/-) indicated that Otx2 expression under the control of this enhancer is essential to the ...[more]