Ontology highlight
ABSTRACT:
SUBMITTER: Kim TD
PROVIDER: S-EPMC1838531 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Kim Tae-Don TD Woo Kyung-Chul KC Cho Sungchan S Ha Dae-Cheong DC Jang Sung Key SK Kim Kyong-Tai KT
Genes & development 20070401 7
The circadian rhythm of pineal melatonin requires the nocturnal increment of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase [AANAT]) protein. To date, only limited information is available in the critical issue of how AANAT protein expression is up-regulated exclusively at night regardless of its species-specific mRNA profiles. Here we show that the circadian timing of AANAT protein expression is regulated by rhythmic translation of AANAT mRNA. This rhythmic control is mediate ...[more]