Ontology highlight
ABSTRACT:
SUBMITTER: Hoshino H
PROVIDER: S-EPMC1839001 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Hoshino Hideharu H Uchida Tsukasa T Otsuki Toshiaki T Kawamoto Shoko S Okubo Kousaku K Takeichi Masatoshi M Chisaka Osamu O
Molecular biology of the cell 20070117 4
During their migration to the periphery, cranial neural crest cells (NCCs) are repulsed by an ErbB4-dependent cue(s) in the mesenchyme adjoining rhombomeres (r) 3 and 5, which are segmented hindbrain neuromeres. ErbB4 has many ligands, but which ligand functions in the above system has not yet been clearly determined. Here we found that a cornichon-like protein/cornichon homolog 2 (CNIL/CNIH2) gene was expressed in the developing chick r3 and r5. In a cell culture system, its product facilitated ...[more]