Clustering of genes into regulons using integrated modeling-COGRIM.
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ABSTRACT:
SUBMITTER: Chen G
PROVIDER: S-EPMC1839128 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Publications
Clustering of genes into regulons using integrated modeling-COGRIM.
Chen Guang G Jensen Shane T ST Stoeckert Christian J CJ
Genome biology 20070101 1
We present a Bayesian hierarchical model and Gibbs Sampling implementation that integrates gene expression, ChIP binding, and transcription factor motif data in a principled and robust fashion. COGRIM was applied to both unicellular and mammalian organisms under different scenarios of available data. In these applications, we demonstrate the ability to predict gene-transcription factor interactions with reduced numbers of false-positive findings and to make predictions beyond what is obtained wh ...[more]
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