Ontology highlight
ABSTRACT:
SUBMITTER: Ybot-Gonzalez P
PROVIDER: S-EPMC1839770 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Ybot-Gonzalez Patricia P Savery Dawn D Gerrelli Dianne D Signore Massimo M Mitchell Claire E CE Faux Clare H CH Greene Nicholas D E ND Copp Andrew J AJ
Development (Cambridge, England) 20070117 4
Planar-cell-polarity (PCP) signalling is necessary for initiation of neural tube closure in higher vertebrates. In mice with PCP gene mutations, a broad embryonic midline prevents the onset of neurulation through wide spacing of the neural folds. In order to evaluate the role of convergent extension in this defect, we vitally labelled the midline of loop-tail (Lp) embryos mutant for the PCP gene Vangl2. Injection of DiI into the node, and electroporation of a GFP expression vector into the midli ...[more]