Ontology highlight
ABSTRACT:
SUBMITTER: Huesmann GR
PROVIDER: S-EPMC1847391 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Huesmann Graham R GR Clayton David F DF
Neuron 20061201 6
Activation of the protease caspase-3 is commonly thought to cause apoptotic cell death. Here, we show that caspase-3 activity is regulated at postsynaptic sites in brain following stimuli associated with memory (neural activation and subsequent response habituation) instead of cell death. In the zebra finch auditory forebrain, the concentration of caspase-3 active sites increases briefly within minutes after exposure to tape-recorded birdsong. With confocal and immunoelectron microscopy, we loca ...[more]