Ontology highlight
ABSTRACT:
SUBMITTER: Gaskell LJ
PROVIDER: S-EPMC1847671 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Gaskell Louise J LJ Osman Fekret F Gilbert Robert J C RJ Whitby Matthew C MC
The EMBO journal 20070315 7
The Holliday junction (HJ) is a central intermediate of homologous recombination. Its cleavage is critical for the formation of crossover recombinants during meiosis, which in turn helps to establish chiasmata and promote genetic diversity. Enzymes that cleave HJs, called HJ resolvases, have been identified in all domains of life except eukaryotic nuclei. Controversially, the Mus81-Eme1 endonuclease has been proposed to be an example of a eukaryotic nuclear resolvase. However, hitherto little or ...[more]