Ontology highlight
ABSTRACT:
SUBMITTER: Korennykh AV
PROVIDER: S-EPMC1847776 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Korennykh Alexei V AV Piccirilli Joseph A JA Correll Carl C CC
Nature structural & molecular biology 20060409 5
Alpha-sarcin ribotoxins comprise a unique family of ribonucleases that cripple the ribosome by catalyzing endoribonucleolytic cleavage of ribosomal RNA at a specific location in the sarcin/ricin loop (SRL). The SRL structure alone is cleaved site-specifically by the ribotoxin, but the ribosomal context enhances the reaction rate by several orders of magnitude. We show that, for the alpha-sarcin-like ribotoxin restrictocin, this catalytic advantage arises from favorable electrostatic interactions ...[more]