Ontology highlight
ABSTRACT:
SUBMITTER: Alva V
PROVIDER: S-EPMC1847821 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Alva Vikram V Ammelburg Moritz M Söding Johannes J Lupas Andrei N AN
BMC structural biology 20070328
<h4>Background</h4>Histones organize the genomic DNA of eukaryotes into chromatin. The four core histone subunits consist of two consecutive helix-strand-helix motifs and are interleaved into heterodimers with a unique fold. We have searched for the evolutionary origin of this fold using sequence and structure comparisons, based on the hypothesis that folded proteins evolved by combination of an ancestral set of peptides, the antecedent domain segments.<h4>Results</h4>Our results suggest that an ...[more]