Ontology highlight
ABSTRACT:
SUBMITTER: Lacey DL
PROVIDER: S-EPMC1850124 | biostudies-literature | 2000 Aug
REPOSITORIES: biostudies-literature
Lacey D L DL Tan H L HL Lu J J Kaufman S S Van G G Qiu W W Rattan A A Scully S S Fletcher F F Juan T T Kelley M M Burgess T L TL Boyle W J WJ Polverino A J AJ
The American journal of pathology 20000801 2
Osteoprotegerin ligand (OPGL) targets osteoclast precursors and osteoclasts to enhance differentiation and activation, however, little is known about OPGL effects on osteoclast survival. In vitro, the combination of OPGL + colony-stimulating factor-1 (CSF-1) is required for optimal osteoclast survival. Ultrastructurally, apoptotic changes were observed in detached cells and culture lysates exhibited elevated caspase 3 activity, particularly in cultures lacking CSF-1. DEVD-FMK (caspase 3 inhibito ...[more]