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Isolation and localization of type IIb Na/Pi cotransporter in the developing rat lung.


ABSTRACT: Differential display analysis of rat lung at different developmental stages identified a fragment, HG80, which appeared on embryonic day 16.5 and thereafter. A full-length cDNA derived from a cDNA library of newborn rat lung probed with HG80 was the rat counterpart of sodium-dependent phosphate transporter type IIb and was designated rNaPi IIb. In situ hybridization showed that rNaPi IIb was expressed in type II alveolar cells, suggesting a role in the synthesis of surfactant in the alveoli. The time-dependent changes in localization of this gene in the developing lung and its possible use as a type II pneumocyte marker are discussed.

SUBMITTER: Hashimoto M 

PROVIDER: S-EPMC1850224 | biostudies-literature | 2000 Jul

REPOSITORIES: biostudies-literature

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Isolation and localization of type IIb Na/Pi cotransporter in the developing rat lung.

Hashimoto M M   Wang D Y DY   Kamo T T   Zhu Y Y   Tsujiuchi T T   Konishi Y Y   Tanaka M M   Sugimura H H  

The American journal of pathology 20000701 1


Differential display analysis of rat lung at different developmental stages identified a fragment, HG80, which appeared on embryonic day 16.5 and thereafter. A full-length cDNA derived from a cDNA library of newborn rat lung probed with HG80 was the rat counterpart of sodium-dependent phosphate transporter type IIb and was designated rNaPi IIb. In situ hybridization showed that rNaPi IIb was expressed in type II alveolar cells, suggesting a role in the synthesis of surfactant in the alveoli. The  ...[more]

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