Isolation and localization of type IIb Na/Pi cotransporter in the developing rat lung.
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ABSTRACT:
SUBMITTER: Hashimoto M
PROVIDER: S-EPMC1850224 | biostudies-literature | 2000 Jul
REPOSITORIES: biostudies-literature
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Isolation and localization of type IIb Na/Pi cotransporter in the developing rat lung.
Hashimoto M M Wang D Y DY Kamo T T Zhu Y Y Tsujiuchi T T Konishi Y Y Tanaka M M Sugimura H H
The American journal of pathology 20000701 1
Differential display analysis of rat lung at different developmental stages identified a fragment, HG80, which appeared on embryonic day 16.5 and thereafter. A full-length cDNA derived from a cDNA library of newborn rat lung probed with HG80 was the rat counterpart of sodium-dependent phosphate transporter type IIb and was designated rNaPi IIb. In situ hybridization showed that rNaPi IIb was expressed in type II alveolar cells, suggesting a role in the synthesis of surfactant in the alveoli. The ...[more]
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