Ontology highlight
ABSTRACT:
SUBMITTER: Hiroyasu M
PROVIDER: S-EPMC1850668 | biostudies-literature | 2002 Feb
REPOSITORIES: biostudies-literature
Hiroyasu Makoto M Ozeki Munetaka M Kohda Haruyasu H Echizenya Michiko M Tanaka Tomoyuki T Hiai Hiroshi H Toyokuni Shinya S
The American journal of pathology 20020201 2
Oxidative tissue damage has been shown to be associated with carcinogenesis. In human cancers p16(INK4A) is one of the most frequently mutated tumor suppressor genes. The present study used the ferric nitrilotriacetate (Fe-NTA)-induced rat renal carcinogenesis model to determine whether oxidative damage can cause specific allelic loss of p16 (INK4A). By the use of fluorescent in situ hybridization in combination with imprint cytology at single-cell resolution, we found that the number of renal t ...[more]