Ontology highlight
ABSTRACT:
SUBMITTER: Graff L
PROVIDER: S-EPMC1850890 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
Graff Lothar L Frungieri Mónica M Zanner Robert R Pohlinger Agnes A Prinz Christian C Gratzl Manfred M
The American journal of pathology 20020501 5
We recently found that human small cell lung carcinomas (SCLCs) express, in addition to other neuroendocrine markers, vesicular monoamine transporters. Our present results indicate that SCLCs are histaminergic. We detected the biosynthetic enzyme histidine decarboxylase by immunohistochemistry in paraffin sections of 12 biopsies of SCLC tumors. This finding was supported by immunoblotting and reverse transcription-polymerase chain reaction experiments using established SCLC cell lines, frozen an ...[more]